Mixing Vyvanse with Yogurt: Administration Guidance
Yes, patients can mix Vyvanse capsule contents with yogurt in the morning, and this is an FDA-approved administration method that does not affect efficacy. 1
FDA-Approved Administration Methods
The FDA label explicitly permits mixing Vyvanse capsule contents with specific foods and liquids 1:
- Open the capsule and mix the entire contents with yogurt, water, or orange juice
- If compacted powder is present, use a spoon to break it apart
- Mix until completely dispersed and consume the entire mixture immediately
- Do not store the mixture—it must be consumed right away 1
Important Administration Requirements
The entire capsule contents must be consumed in a single dose 1:
- Do not take anything less than one full capsule per day
- A single dose should never be divided
- The active ingredient (lisdexamfetamine) dissolves completely when dispersed
- An inactive film may remain in the container after consumption—this is normal and does not contain active drug 1
Addressing Reduced Efficacy
If Vyvanse appears less effective, mixing with yogurt will not enhance efficacy—the problem requires dose adjustment or medication change 1:
- The starting dose is 30 mg once daily in the morning
- Dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals
- Maximum recommended dosage is 70 mg once daily 1
Take Vyvanse in the morning with or without food; avoid afternoon doses due to insomnia risk 1
When Efficacy Remains Inadequate
If optimal dosing (up to 70 mg daily) does not provide adequate symptom control, consider alternative ADHD medications rather than altering administration method 2:
- Methylphenidate formulations are first-line alternatives with various extended-release options
- Amphetamine mixed salts (Adderall XR) starting at 10 mg once daily with similar mechanism but different pharmacokinetics
- Dextroamphetamine (Dexedrine) available in immediate and extended-release formulations, titrated in 5 mg weekly increments to maximum 50 mg daily 2
Common Pitfall to Avoid
Do not assume that mixing with yogurt will improve reduced efficacy—this administration method is for convenience or swallowing difficulty, not for enhancing drug effect 1. The prodrug lisdexamfetamine is hydrolyzed to active d-amphetamine in the blood regardless of administration method 3. If symptoms are inadequately controlled, the issue is dosing or medication selection, not administration technique.