Medication Dosing for 26-Year-Old Male, 35.9 kg
I cannot provide specific medication doses without knowing which medication you are asking about. However, I can provide weight-based dosing guidance for the medications discussed in the available evidence.
Tuberculosis Medications (if applicable)
For a patient weighing 35.9 kg, tuberculosis medication doses would be calculated as follows:
First-Line TB Medications - Daily Dosing 1
- Isoniazid (INH): 5 mg/kg = 180 mg daily (maximum 300 mg) 1
- Rifampin (RIF): 10 mg/kg = 360 mg daily (maximum 600 mg) 1
- Pyrazinamide (PZA): For weight <40 kg, use 1,000 mg daily (18.2-25.0 mg/kg range) 1
- Ethambutol (EMB): 15-20 mg/kg = 540-720 mg daily (maximum 1,000 mg) 1
Intermittent TB Dosing (if using twice-weekly regimen) 1
- Isoniazid: 15 mg/kg = 540 mg twice weekly (maximum 900 mg) 1
- Rifampin: 10 mg/kg = 360 mg twice weekly (maximum 600 mg) 1
- Pyrazinamide: For weight <40 kg, use 2,000 mg twice weekly (36.4-50.0 mg/kg range) 1
- Ethambutol: 50 mg/kg = 1,800 mg twice weekly (maximum 4,000 mg) 1
Weight Management Medications (if applicable)
Qsymia (Phentermine/Topiramate ER) 2
The dosing schedule is fixed and not weight-based:
- Initial dose: 3.75 mg phentermine/23 mg topiramate daily for 14 days 2
- Standard dose: 7.5 mg phentermine/46 mg topiramate daily after initial period 2
- Titration dose: 11.25 mg phentermine/69 mg topiramate daily if needed 2
- Maximum dose: 15 mg phentermine/92 mg topiramate daily 2
This patient's low weight (35.9 kg) requires special consideration, as Qsymia is typically studied in patients with obesity. 1, 2
Tirzepatide 3
Tirzepatide dosing is standardized and not weight-based:
- Starting dose: 2.5 mg subcutaneously once weekly for 4 weeks 3
- Escalation: Increase by 2.5 mg increments every 4 weeks 3
- Maintenance doses: 10 mg or 15 mg once weekly 3
Given this patient's significantly low body weight (35.9 kg), tirzepatide would likely be contraindicated unless there is a specific medical indication, as it is designed for weight management in overweight/obese patients. 3
Critical Considerations for This Patient
This patient's weight of 35.9 kg is significantly below normal for a 26-year-old male (BMI likely <18.5), which raises important clinical concerns:
- Weight management medications like Qsymia and tirzepatide are contraindicated in underweight patients 1, 2, 3
- For tuberculosis treatment, standard weight-based dosing applies, but close monitoring for adverse effects is essential given lower body mass 1
- Any medication dosing in an underweight adult requires careful consideration of drug distribution, metabolism, and potential toxicity 4
Please specify which medication you need dosing for, and I can provide more targeted guidance.