Can Tamiflu Capsules Be Dissolved in Water?
Yes, Tamiflu (oseltamivir) capsules can be opened and the contents mixed with liquid for administration, particularly when patients cannot swallow capsules whole. 1, 2
Formulation Options
Oseltamivir is available in two primary formulations 1, 3, 4:
- Capsules: 30 mg, 45 mg, and 75 mg strengths 1, 3
- Oral suspension: Powder that reconstitutes to 6 mg/mL concentration (this is the preferred formulation for patients who cannot swallow capsules) 1, 2
Administration Guidance for Capsule Contents
If the commercially manufactured oral suspension is not available, the capsule contents can be used as an alternative. 1 The FDA label specifically states that oseltamivir phosphate for oral suspension is "the preferred formulation for patients who cannot swallow capsules," implying that capsule contents can be used when the suspension is unavailable 2.
- The American Academy of Pediatrics notes that "if the commercially manufactured oral suspension is not available, a suspension can be compounded by retail pharmacies (final concentration also 6 mg/mL), based on instructions on the package label" 1
- This compounding process involves opening capsules and mixing the contents appropriately 1
Important Administration Considerations
- Take with food when possible: Administration with meals may improve gastrointestinal tolerability, as nausea and vomiting are common adverse effects 1, 3, 5
- Timing is critical: Treatment must be initiated within 48 hours of symptom onset for maximum effectiveness 3, 2
- The medication can be administered with or without food, though food improves tolerance 1, 4, 2
Critical Pitfall to Avoid
Do not attempt to dissolve capsules in water at home without proper guidance. The commercially available oral suspension or pharmacy-compounded suspension should be used instead, as these ensure accurate dosing and appropriate stability 1, 2. If you need a liquid formulation, contact your pharmacist to either obtain the manufactured oral suspension or have them properly compound a suspension from the capsules using standardized procedures 1.