From the Research
CJC-1295/Ipamorelin should not be used without medical supervision due to its potential risks and lack of FDA approval for human use. This combination consists of two peptides that stimulate growth hormone release: CJC-1295, which extends the half-life of growth hormone-releasing hormone, and Ipamorelin, which mimics ghrelin to trigger growth hormone secretion.
Key Points to Consider
- Typical protocols involve subcutaneous injections of 200-300 mcg of each peptide daily, usually before bedtime to align with natural growth hormone pulses.
- The combination is sometimes used off-label by athletes and anti-aging enthusiasts to potentially increase muscle mass, reduce body fat, improve recovery, and enhance sleep quality.
- Side effects may include water retention, headaches, numbness at injection sites, and potential impacts on insulin sensitivity.
- Long-term safety data is limited, and these peptides could potentially affect natural hormone production.
- Blood work monitoring is essential if used, and the peptides require refrigeration and proper reconstitution with bacteriostatic water.
Evidence-Based Recommendations
According to a study published in the Journal of Clinical Endocrinology and Metabolism 1, CJC-1295 has been shown to increase growth hormone and insulin-like growth factor I secretion in healthy adults. However, the study also highlights the importance of careful dosing and monitoring due to the potential for adverse effects.
Important Considerations
- Ipamorelin has been shown to be a selective growth hormone secretagogue with a high degree of specificity for GH release, similar to that of growth hormone-releasing hormone (GHRH) 2.
- A netnography study published in Substance Use & Misuse 3 found that female users of CJC-1295 reported using the peptide for weight loss, muscle enhancement, and improved sleep, but also expressed concerns about the potential consequences of use, including gender variations in growth hormone pulses.
- It is crucial to consult with a healthcare provider before considering the use of CJC-1295/Ipamorelin, as they can help weigh the potential benefits and risks and provide guidance on safe use.