From the FDA Drug Label
Each L-METHYLFOLATE CALCIUM 7.5mg tablet contains 7. 5 mg of L-METHYLFOLATE CALCIUM Each L-METHYLFOLATE CALCIUM 15mg tablet contains 15mg of L-METHYLFOLATE CALCIUM
The dose of L-methylfolate is available in two strengths:
- 7.5mg
- 15mg 1
From the Research
The recommended dose of L-methylfolate is 15 mg daily for depression augmentation, as it has been shown to have modest efficacy in antidepressant-treated adults with major depressive disorder. This dose is based on the most recent and highest quality study available, which is a systematic review and meta-analysis of L-methylfolate augmentation in depressive disorders 2. The study found that adjunctive L-methylfolate was associated with a small effect versus antidepressant monotherapy, and a meta-analysis of continuous measures of depressive symptoms showed a similar effect of adjunctive L-methylfolate.
Some key points to consider when prescribing L-methylfolate include:
- Starting with a dose of 7.5 mg daily and increasing to 15 mg if needed based on symptom response
- Taking L-methylfolate with food to enhance absorption
- Consistency in daily timing to maintain stable blood levels
- Unlike folic acid, L-methylfolate is the active form of folate that bypasses the conversion process in the body, making it more effective for people with impaired folate metabolism
- Common side effects are minimal but may include nausea or irritability
- Interactions may occur with medications like methotrexate or certain anti-seizure drugs, so consultation with a healthcare provider is recommended before starting L-methylfolate.
It's also important to note that L-methylfolate may take 4-6 weeks to show full benefits, particularly for mood symptoms, and that it should be used under the guidance of a healthcare provider. The use of L-methylfolate as an adjunctive treatment for depression is supported by the study 2, which found that it may have modest efficacy in antidepressant-treated adults with major depressive disorder.