What are the additional signs and symptoms of breast cancer to monitor?

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Last updated: March 31, 2025View editorial policy

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From the Guidelines

If you suspect breast cancer, it is crucial to watch for several key signs and symptoms beyond a lump, including changes in breast size or shape, skin dimpling or puckering, nipple changes, persistent pain, and unusual redness or thickening of breast skin, as these can significantly impact morbidity, mortality, and quality of life. These signs and symptoms can be remembered using the acronym BREAST, which signifies Breast mass, Retraction, Edema, Axillary mass, Scaly nipple, and Tender breast 1. It is essential to be aware of these signs as they can occur with benign conditions but warrant prompt medical evaluation, especially if they persist or worsen.

Key Signs and Symptoms

  • Changes in breast size or shape
  • Skin dimpling or puckering
  • Nipple changes (such as inversion, discharge, or redness)
  • Persistent pain in the breast or armpit
  • Swelling in the armpit or collarbone area
  • Unusual redness, warmth, or thickening of breast skin (sometimes resembling orange peel)

According to the American Cancer Society/American Society of Clinical Oncology breast cancer survivorship care guideline, physicians should educate and counsel patients about the signs and symptoms of local or regional recurrence, including new lumps, rash or skin changes on the breast or chest wall, chest pain, changes in the contour/shape/size of the breast, and swelling of the breast or arm 1.

Regular breast self-exams can help individuals become familiar with their normal breast tissue, making it easier to detect changes. Remember that early detection significantly improves treatment outcomes, so don't delay seeking medical attention if you notice any concerning changes, even if you recently had a normal mammogram. The most recent and highest quality study, although not directly referenced here, would typically guide the recommendation, but based on the provided evidence, prompt evaluation of any suspicious breast changes is critical for improving morbidity, mortality, and quality of life outcomes.

From the FDA Drug Label

Women taking or having previously taken tamoxifen should be instructed to seek prompt medical attention for new breast lumps, vaginal bleeding, gynecologic symptoms (menstrual irregularities, changes in vaginal discharge, or pelvic pain or pressure), symptoms of leg swelling or tenderness, unexplained shortness of breath, or changes in vision The signs and symptoms to watch for if you suspect breast cancer include:

  • New breast lumps
  • Vaginal bleeding
  • Gynecologic symptoms, such as:
  • Menstrual irregularities
  • Changes in vaginal discharge
  • Pelvic pain or pressure
  • Symptoms of leg swelling or tenderness
  • Unexplained shortness of breath
  • Changes in vision 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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