Cost of Lokelma 5 mg Once Daily
I cannot provide specific pricing information for Lokelma (sodium zirconium cyclosilicate) 5 mg once daily from the evidence provided, as none of the studies include cost data for this medication.
What the Evidence Shows
The available evidence focuses on clinical efficacy and safety of sodium zirconium cyclosilicate (SZC/Lokelma) for hyperkalemia treatment, but does not contain pricing information:
Clinical efficacy: SZC 5 mg once daily effectively maintains normokalaemia (serum potassium 3.5-5.0 mmol/L) in patients with hyperkalemia, with 58.6% of patients achieving normokalaemia at day 29 in clinical trials 1
Dosing regimen: The typical maintenance dose is 5 g once daily after an initial correction phase with 10 g three times daily 2, 3
Long-term use: Approximately 17% of patients in real-world Italian practice continued SZC therapy for ≥90 days, with long-term users showing reduced healthcare costs compared to short-term users 4
Important Context
The provided evidence tables contain pricing for numerous other medications (NSAIDs, weight loss medications, diabetes medications, prostate cancer treatments, HIV prophylaxis agents) but do not include Lokelma/SZC pricing 5.
To obtain accurate current pricing for a 1-month supply of Lokelma 5 mg once daily, you would need to:
- Contact the manufacturer (AstraZeneca) directly
- Check pharmacy benefit manager formularies
- Consult current wholesale acquisition cost databases
- Review patient assistance programs that may be available