From the Research
Starting cabergoline 4 days after egg retrieval can still be effective for preventing or treating ovarian hyperstimulation syndrome (OHSS), as supported by the most recent study in 2021 1. The standard regimen is 0.5 mg daily for 7-10 days, starting either on the day of trigger injection or within 1-2 days after egg retrieval. However, since OHSS symptoms often peak 5-7 days after retrieval, beginning treatment at day 4 may still help reduce symptom severity by blocking vascular endothelial growth factor receptors, which decreases vascular permeability and fluid leakage. Some key points to consider:
- The incidence of moderate to severe OHSS was lower after cabergoline administration, as shown in a study from 2015 2.
- Cabergoline has a favorable effect on the prevention of moderate to severe OHSS affiliated with ovarian volume reduction, as demonstrated in a study from 2012 3.
- The risk of 'early' OHSS decreased significantly with cabergoline administration, as reported in a study from 2008 4.
- Administration of cabergolin can prevent incidence of OHSS and does not appear to effect on its severity, as found in a study from 2013 5. For maximum effectiveness, start the medication immediately rather than delaying further, and complete the full prescribed course. Common side effects include nausea, headache, and dizziness. Contact your fertility specialist if you experience severe abdominal pain, rapid weight gain, severe nausea/vomiting, decreased urination, or difficulty breathing, as these may indicate worsening OHSS requiring immediate medical attention.