From the Guidelines
Izempic should be injected into the upper third anterior lateral aspect of the thigh, avoiding the inner thigh area and any scars or lipodystrophy. When injecting izempic into the thigh, it is essential to choose a spot with adequate subcutaneous fat tissue to ensure proper absorption of the medication into the bloodstream 1. The recommended injection technique involves inserting a 4-mm pen needle at a 90-degree angle, which is suitable for all adults regardless of age, sex, ethnicity, or BMI 1. To avoid intramuscular injections, especially in lean individuals, a correctly lifted skinfold may be necessary if the presumed skin surface to muscle distance is less than the needle length 1. Key considerations for injection sites include:
- Avoiding bony prominences by 1 to 2 adult fingerbreadths
- Avoiding scars and lipodystrophy
- Rotating injection sites to prevent tissue damage and ensure proper absorption
- Using a 4-mm pen needle inserted at 90 degrees for all adults
- Considering the type of medication and the time of day when selecting injection sites 2. It is crucial to follow the correct injection technique and rotate injection sites to prevent lipodystrophy and ensure proper absorption of izempic 1, 2.
From the FDA Drug Label
• Administer OZEMPIC subcutaneously to the abdomen, thigh, or upper arm. Instruct patients to use a different injection site each week when injecting in the same body region. You can inject izempic (semaglutide) in your thigh, but you should use a different injection site each week when injecting in the same body region 3.
From the Research
Injection Site for Izempic (Semaglutide)
The studies provided do not specifically mention the injection site for Izempic (semaglutide) in the thigh. However, we can discuss the general guidelines for injecting semaglutide:
- Semaglutide is typically administered subcutaneously (under the skin) once a week 4, 5, 6, 7, 8.
- The injection site is usually rotated to avoid injection site reactions, but the specific location on the thigh is not mentioned in the provided studies.
Subcutaneous Injection Sites
Subcutaneous injections can be administered in various areas of the body, including:
- The abdomen (around the navel)
- The upper outer thigh
- The upper arm
- The buttocks
It is essential to consult the prescribing information or a healthcare professional for specific guidance on injecting Izempic (semaglutide), including the recommended injection site and rotation schedule 4, 5, 6, 7, 8.
Important Considerations
When injecting semaglutide, it is crucial to:
- Follow the recommended injection technique and site rotation to minimize the risk of injection site reactions
- Monitor for potential side effects, such as nausea, diarrhea, and vomiting, which are commonly reported with semaglutide use 5, 7
- Consult a healthcare professional if you have any questions or concerns about injecting Izempic (semaglutide) or experience any adverse effects.