From the FDA Drug Label
Lymphogranuloma venereum caused by Chlamydia trachomatis. The drug of choice for Lymphogranuloma Venereum is doxycycline. The exact regimen is not specified in the provided drug label, however, doxycycline is indicated for the treatment of this infection 1.
From the Research
The drug of choice for lymphogranuloma venereum (LGV) is doxycycline, administered at a dose of 100 mg orally twice daily for 7 days, as this regimen has been shown to be effective in eradicating the infection 2.
Key Considerations
- The treatment duration of 7 days is supported by a recent study that demonstrated successful LGV eradication in all patients treated with this regimen, with the exception of one case of reinfection 2.
- The use of doxycycline for 7 days may simplify patient management, reduce cost, and improve antimicrobial stewardship 2.
- Alternative regimens, such as erythromycin or azithromycin, may be considered for patients who cannot take doxycycline, but the evidence for these regimens is less robust 3, 4, 5, 6.
Patient Management
- Treatment should be initiated promptly upon diagnosis to prevent complications such as lymphatic obstruction, rectal strictures, or genital elephantiasis.
- Sexual partners from the 60 days before symptom onset should also be evaluated and treated for chlamydial infection.
- Patients should abstain from sexual activity until they and their partners have completed treatment to prevent reinfection.