What is the recommended treatment for an ankle sprain?

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Last updated: November 17, 2025View editorial policy

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Ankle Sprain Treatment

Implement the PRICE protocol (Protection, Rest, Ice, Compression, Elevation) immediately, followed by early functional rehabilitation with a semirigid ankle brace and supervised exercise therapy beginning within 48-72 hours after injury. 1

Immediate Acute Management (First 3-5 Days)

  • Apply ice (surrounded by a damp cloth) for 20-30 minutes at a time to reduce pain and swelling, avoiding direct skin contact to prevent cold injury 1
  • Use a compression wrap to promote comfort while ensuring circulation is not compromised 1
  • Elevate the injured ankle above heart level 1
  • Apply a semirigid ankle brace immediately—this is the most cost-effective option and superior to taping or elastic bandages 1, 2
  • Consider NSAIDs to reduce pain and swelling in the acute phase, which may decrease time to return to usual activities 1, 2
  • Avoid heat application for acute ankle injuries 1

Early Functional Rehabilitation (Starting 48-72 Hours Post-Injury)

Functional treatment with early mobilization is strongly preferred over prolonged immobilization, as it results in return to sports 4.6 days sooner and return to work 7.1 days sooner 1, 2

  • Begin supervised exercise therapy as soon as possible after the initial 3-5 day RICE period—this has the strongest evidence (level 1) for effectiveness 1, 2

  • Supervised exercises are superior to non-supervised home programs and must include: 1, 2

    • Range of motion exercises
    • Proprioception training (balance and position sense)
    • Strengthening exercises targeting muscle deficits
    • Coordination exercises
    • Sport-specific functional activities
  • Continue wearing the semirigid ankle brace during rehabilitation and return to activity, as bracing has level 1 evidence for preventing recurrent sprains 2

Follow-Up and Reassessment

  • Schedule re-examination 3-5 days after injury for accurate diagnosis and treatment planning, as clinical assessment of ligament damage is optimized when swelling has decreased 1, 2
  • Manual mobilization may be added only in combination with other treatment modalities to enhance treatment effect 1, 2

Special Consideration: High Ankle Sprains

  • High ankle sprains (syndesmosis injuries) can be detected using the crossed-leg test, where pressure applied to the medial knee produces pain in the syndesmosis area 1, 2
  • These injuries require more intensive rehabilitation and longer recovery time 1
  • The same functional treatment principles apply, but expect extended timelines 2

Critical Pitfalls to Avoid

  • Avoid prolonged immobilization—it shows no benefits compared to functional treatment and delays recovery 1, 2
  • Do not apply heat to acute ankle injuries 1
  • Inadequate rehabilitation leads to chronic problems including decreased range of motion, persistent pain, and joint instability 1, 2
  • RICE alone without subsequent exercise therapy has no positive influence on long-term patient function 2
  • Excessive rest beyond 3-5 days delays recovery and return to activities 2

Prevention of Recurrent Injury

  • Continue wearing a semirigid ankle brace during high-risk activities—bracing is superior to taping and neuromuscular training for preventing recurrent sprains (level 1 evidence) 2
  • Incorporate proprioceptive and neuromuscular training exercises into regular training activities for athletes with recurrent sprains 1, 2

References

Guideline

Ankle Sprain Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Rehabilitation Guidelines for High Ankle Sprains

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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