Amphetamine Salts ER and Generic Adderall ER: Same Medication
Yes, amphetamine salts extended release (ER) is the same medication as generic Adderall ER—both contain the identical active ingredient: a 3:1 mixture of dextroamphetamine to levoamphetamine salts in an extended-release formulation. 1
Composition and Formulation
- Adderall ER contains mixed amphetamine salts consisting of approximately 76% D-amphetamine and 24% L-amphetamine 2, 1
- Generic versions labeled as "amphetamine salts ER" or "mixed amphetamine salts ER" contain this identical enantiomer ratio and are bioequivalent to brand-name Adderall XR 3
- The extended-release mechanism provides a gradual ascending increase in amphetamine plasma concentration throughout the day, avoiding the multiple peaks seen with immediate-release formulations 4, 5
Clinical Equivalence
- Generic amphetamine salts ER products must demonstrate bioequivalence to brand-name Adderall XR through FDA-approved studies 3
- The pharmacokinetic profile, therapeutic effects, and side effect profile are equivalent between generic and brand formulations when bioequivalence is established 3
- Both formulations produce the same dopamine release patterns in the striatum and have identical mechanisms of action 2
Prescribing and Dispensing Considerations
- When prescribers write "amphetamine salts ER" or "mixed amphetamine salts ER," pharmacies will dispense generic Adderall ER unless the brand is specifically requested 1
- Starting dose is 10 mg once daily in the morning for both generic and brand formulations, with weekly 5-10 mg increments based on clinical response 5, 6
- Maximum recommended daily dose is 40-50 mg for both formulations 5
Important Distinction from Other Amphetamine Products
- Dexedrine (dextroamphetamine) contains only the D-enantiomer, making it pharmacologically distinct from Adderall/amphetamine salts which contain both D- and L-enantiomers 4, 6, 1
- The presence of L-amphetamine in Adderall/amphetamine salts ER can be detected in urine drug screens and distinguishes it from pure dextroamphetamine products 1
- Adderall produces significantly greater and more prolonged dopamine release compared to pure D-amphetamine due to its unique enantiomer combination 2
Monitoring Requirements
- Regular monitoring of blood pressure, pulse, weight, and height should occur at baseline and with each dose adjustment for both generic and brand formulations 7, 5
- Assess therapeutic effects and side effects (decreased appetite, sleep disturbances, headaches) before each dose increase 5
- Morning administration is recommended to minimize sleep disturbances regardless of whether generic or brand is used 7, 5