From the Guidelines
Histex drops are not recommended for use in children under 6 years of age. This is due to concerns over the safety of antihistamine medications in young children, as highlighted in a study published in the Journal of Allergy and Clinical Immunology 1. The study notes that the efficacy of cold and cough medications, including antihistamines, has not been established for children younger than 6 years, and their use can lead to potential toxicity.
Key Points to Consider
- The use of OTC cough and cold medications, including antihistamines like Histex, should be avoided in children below 6 years of age due to safety concerns 1.
- Antihistamine-decongestant combination products have been shown to be ineffective for symptoms of upper respiratory tract infections in young children, and their safety has been a concern 1.
- Second-generation antihistamines, such as cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine, have been found to be well-tolerated and safe for use in young children, making them a preferable alternative for pediatric use 1.
Recommendations for Use
For children over 6 years, it is crucial to follow the recommended dosage and consult with a pediatrician before administering any medication, including Histex. However, given the safety concerns associated with first-generation antihistamines like carbinoxamine in Histex drops, it is advisable to opt for second-generation antihistamines that have a better safety profile in children. Always prioritize consulting a pediatrician for the most appropriate and safe treatment options for children under 6 years of age.
From the FDA Drug Label
Pediatric Use The safety and efficacy of Clemastine Fumarate Syrup has been confirmed in the pediatric population (age 6 years through 12) Safety and dose tolerance studies have confirmed children 6 through 11 years tolerated dosage ranges of 0.75 to 2. 25 mg clemastine.
Histex drops can be used in children, but only in those 6 years and older, as the safety and efficacy of Clemastine Fumarate Syrup has been confirmed in this age group 2. Caution is advised when administering antihistamines to children, as they may be more susceptible to adverse reactions, including hallucinations, convulsions, and death in cases of overdosage 2.
From the Research
Histex Drops in Children
- Histex drops are an antihistamine medication, and their use in children can be considered based on the available evidence on antihistamines in general.
- According to a study published in 2023 3, second-generation H1 antihistamines have been established as safe and effective in adult and pediatric allergic rhinitis populations.
- The same study mentions that robust data on the regular use of H1 antihistamines for urticaria have been published, including in the management of children 3.
- However, it is essential to note that the specific medication Histex drops is not mentioned in the provided studies.
- A study from 2009 4 compared the effects of first- and second-generation antihistamines on histamine- and allergen-induced skin reactions, but it does not provide information on the use of Histex drops in children.
- Other studies 5, 6, 7 discuss the use of antihistamines in various allergic conditions, but they do not specifically address the use of Histex drops in children.
- Therefore, while there is evidence supporting the use of antihistamines in children, there is no direct information available on the use of Histex drops in this population.