Can Lizdelvi Cause Hair Loss and Fatigue?
Based on the available evidence, I cannot provide a definitive answer about whether Lizdelvi causes hair loss and fatigue because no evidence about this specific medication was provided in the clinical guidelines, drug labels, or research studies reviewed.
Critical Gap in Evidence
The evidence provided does not contain any information about "Lizdelvi" - no FDA drug label, clinical guidelines, or research studies addressing this medication were included in the materials reviewed. Without access to:
- FDA-approved drug labeling for Lizdelvi
- Clinical trial safety data
- Post-marketing surveillance reports
- Prescribing information
I cannot make evidence-based statements about its adverse effect profile.
General Context on Drug-Related Hair Loss and Fatigue
While I cannot comment specifically on Lizdelvi, the evidence does provide context about these symptoms with other medications:
Hair Loss (Alopecia) as a Drug Side Effect
- Chemotherapy-induced alopecia occurs in approximately 48% of chemotherapy treatments with grade 2 severity (>50% hair loss), typically beginning 1-3 weeks after therapy initiation 1
- Acitretin causes hair loss in up to 75% of patients, though frank alopecia occurs in <10%, with higher rates in women at doses exceeding 17.5 mg per day 2
- Ethionamide can cause alopecia as an endocrine disturbance 2
Fatigue as a Drug Side Effect
- Hepatitis C antivirals commonly cause fatigue: elbasvir/grazoprevir 2, sofosbuvir/velpatasvir 2, and daclatasvir 2 all list fatigue as a frequent adverse event
- Antiretroviral agents including darunavir/ritonavir and atazanavir cause fatigue and gastrointestinal side effects 2
- Lorcaserin for obesity lists fatigue among the most common side effects 2
What You Should Do
If you are experiencing hair loss and fatigue while taking Lizdelvi, you should:
- Contact your prescribing physician immediately to report these symptoms
- Do not discontinue the medication without medical guidance, as the benefits may outweigh reversible cosmetic or subjective side effects
- Request review of the official prescribing information for Lizdelvi to determine if these are known adverse effects
- Consider evaluation for alternative causes of these symptoms unrelated to the medication
Important Caveat
The absence of evidence in this review does not mean Lizdelvi does not cause these side effects - it simply means the specific drug information was not available in the materials provided. Always consult the FDA-approved prescribing information and your healthcare provider for medication-specific safety information.