No Medications Can Safely Increase Penis Size in Men with Normal Anatomy
There are no FDA-approved medications that increase penis size, and no pharmacological interventions have demonstrated safe and effective penile enlargement in men with normal penile anatomy. 1
Evidence-Based Reality of Penile Enhancement
The scientific literature is unequivocal on this topic:
- Pills, supplements, and topical medications marketed for penile enlargement have no proven efficacy and are not supported by any credible scientific evidence 2, 1
- Surgery remains the only method with any scientific basis for penile size modification, though even surgical outcomes are poorly studied and carry significant risks 2
- The vast majority of men seeking penile enlargement actually have normal-sized penises and may suffer from penile dysmorphophobic disorder—a psychological preoccupation with penis size 3
What About Injectable Treatments?
Injectable substances have been attempted but carry unacceptable risks:
- Methacrylate and other injectable fillers can cause severe penile deformity, sexual dysfunction, and fibrosis requiring surgical removal 4
- While some injectable treatments may increase girth, they are associated with high complication rates including penile fibrosis, infection, and devastating functional outcomes 1, 3
- These procedures should be considered experimental and potentially dangerous 3
The Only Evidence-Based Non-Surgical Option
If a patient insists on pursuing enlargement after appropriate counseling:
- Penile traction devices (extenders) are the only non-surgical method with any scientific support, showing modest increases in flaccid length of less than 2 cm 1, 5
- These devices should be considered first-line if any intervention is pursued, as they avoid the risks of surgery or injections 5
- Vacuum devices do NOT increase penile size 1
Critical Clinical Approach
Structured psychological counseling should always be the first intervention, as the majority of men seeking penile enlargement have normal anatomy and, when properly counseled, come to understand their penis is normal and decline further treatment 1
Common Pitfalls to Avoid:
- Do not prescribe PDE5 inhibitors (sildenafil, tadalafil) for size enhancement—these medications treat erectile dysfunction only and do not increase penile dimensions 6, 7
- Do not refer patients for surgical procedures without extensive counseling, as complications are frequent and techniques lack external validation 1
- Recognize that patient dissatisfaction often stems from psychological factors rather than true anatomical abnormality 3
Bottom Line for Clinical Practice
Any penile augmentation procedure beyond counseling and potentially penile extenders should be considered unethical outside of clinical trials due to poor evidence quality, high complication rates, and lack of standardized outcomes assessment 1