From the Research
Isoxazolines are not currently FDA-approved for use in goats, though they are sometimes used off-label by veterinarians. The most common isoxazolines that might be used in goats include fluralaner (Bravecto), afoxolaner (NexGard), and sarolaner (Simparica) 1. When used off-label in goats, typical dosing is based on body weight, similar to small animal applications, with fluralaner often dosed at 25-50 mg/kg orally every 8-12 weeks. These medications work by blocking GABA-gated chloride channels and glutamate-gated chloride channels in parasites, causing paralysis and death of ectoparasites like ticks, fleas, and mites.
Key Considerations
- Before using isoxazolines in goats, consult with a veterinarian as these drugs have not been thoroughly studied in small ruminants and appropriate withdrawal times for milk and meat are not established 1.
- Potential side effects may include neurological symptoms, gastrointestinal upset, and lethargy.
- Alternative approved treatments for external parasites in goats include permethrin-based products, which may be preferable from a regulatory standpoint.
Efficacy and Safety
- The efficacy and safety of isoxazolines against various types of ectoparasites, including fleas, ticks, and mites, have been evaluated in recent studies 2, 1.
- Isoxazolines have been shown to be effective in controlling ectoparasites, but their use in goats requires careful consideration of the potential risks and benefits.
Regulatory Status
- Isoxazolines are not currently approved for use in goats, and their use is considered off-label 1.
- Veterinarians should exercise caution when using isoxazolines in goats and carefully monitor for potential side effects.