What are the risks of Ryeqo?

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Last updated: November 19, 2025View editorial policy

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Ryeqo Risks

I cannot provide specific information about the risks of Ryeqo based on the evidence provided, as none of the studies or guidelines reference this medication.

What the Evidence Shows

The provided literature discusses risks associated with entirely different medications and clinical scenarios:

  • Anaphylaxis management and premedication strategies for contrast media and other agents 1
  • Hydroxychloroquine retinal toxicity screening recommendations 1
  • Thrombopoietin receptor agonists (eltrombopag, romiplostim) for immune thrombocytopenia 1
  • CAR T-cell therapy complications including cytokine release syndrome 1
  • Pulmonary arterial hypertension therapies including riociguat 1
  • Other unrelated medications such as indapamide, polyethylene glycol, telitacicept, and aspirin 2, 3, 4, 5

Clinical Recommendation

To obtain accurate information about Ryeqo's risks, you must consult the FDA-approved prescribing information (drug label) for this specific medication, which was not included in the evidence provided.

What You Need to Know About Ryeqo

Ryeqo (relugolix, estradiol, and norethindrone acetate) is a combination medication used for managing heavy menstrual bleeding associated with uterine fibroids. Without access to its official drug label or relevant clinical guidelines, I cannot provide evidence-based risk information specific to this medication.

Next Steps

  • Review the FDA prescribing information for Ryeqo
  • Consult product monographs from the manufacturer
  • Search for clinical practice guidelines specifically addressing GnRH antagonist combination therapies for uterine fibroids

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Indapamide and Vestibulotoxicity

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Neurotoxicity Assessment of Polyethylene Glycol 3350

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus.

The New England journal of medicine, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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