What is the renal clearance of Gliclazide?

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From the Research

Renal Clearance of Gliclazide

  • The renal clearance of Gliclazide accounts for only 4% of total drug clearance, as stated in the study published in 1991 1.
  • This suggests that Gliclazide is extensively metabolized and that renal clearance plays a minor role in its elimination.
  • There is no direct information on the renal clearance of Gliclazide in the other studies provided, which focus on its pharmacokinetics in different populations 2, 3, its protective effects on renal cells 4, and the pharmacokinetics and safety of another drug, glimepiride, in patients with renal impairment 5.

References

1
Research

The mode of action and clinical pharmacology of gliclazide: a review.

Diabetes research and clinical practice, 1991

2
Research

Pharmacokinetics of gliquidone, glibenclamide, gliclazide and glipizide in middle-aged and aged subjects.

Research communications in molecular pathology and pharmacology, 1999

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