Does amlodipine (calcium channel blocker) cause constipation?

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Last updated: April 1, 2025View editorial policy

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From the Guidelines

Amlodipine is not commonly associated with causing constipation, as it is not listed as a side effect in the most recent and highest quality studies 1.

Side Effects of Amlodipine

The side effects of amlodipine are well-documented, and constipation is not typically one of them. According to the study published in 2015 1, the common side effects of amlodipine include bradycardia, decreased cardiac output, peripheral edema, rash, and gum hyperplasia.

Comparison with Other Medications

In comparison, other calcium channel blockers like nifedipine and diltiazem have been associated with constipation as a side effect 1. However, amlodipine is not typically linked to constipation.

Management of Constipation

If you experience constipation while taking amlodipine, you can try increasing your water intake, consuming more dietary fiber, and engaging in regular physical activity. Over-the-counter stool softeners may also help.

Importance of Medical Advice

It's essential to consult your healthcare provider if constipation becomes severe or persistent, as they might adjust your dosage or recommend an alternative medication. Do not stop taking amlodipine without medical advice, as maintaining blood pressure control is crucial for preventing cardiovascular complications.

From the Research

Amlodipine and Constipation

  • There are no research papers provided that directly investigate the relationship between amlodipine and constipation.
  • The studies provided focus on the effects of fiber supplementation on chronic constipation, and do not mention amlodipine as a potential cause of constipation 2, 3, 4, 5.
  • These studies suggest that fiber supplementation can be effective in improving symptoms of constipation, but do not provide information on the specific effects of amlodipine on bowel movements or constipation.
  • To determine whether amlodipine causes constipation, further research would be needed that specifically investigates this relationship.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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