Standard Dose of Mucinex (Guaifenesin) for Adults
For adults, the standard dose of Mucinex (guaifenesin) is 200-400 mg every 4 hours for immediate-release formulations (maximum 2400 mg/day), or 600-1200 mg every 12 hours for extended-release formulations. 1
Immediate-Release Formulation Dosing
- Adults and children ≥12 years: 10-20 mL (equivalent to 200-400 mg) every 4 hours 1
- Maximum frequency: Do not exceed 6 doses in any 24-hour period 1
- This translates to a maximum daily dose of 2400 mg when using the highest recommended single dose 1
Extended-Release Formulation Dosing
- Standard dose: 1200 mg (two 600 mg tablets) every 12 hours 2, 3
- The extended-release formulation provides bioequivalent steady-state exposure to the immediate-release formulation dosed every 4 hours 2
- This dosing schedule offers convenience with twice-daily administration while maintaining 24-hour therapeutic effect 4
Clinical Considerations
Food effects: Extended-release guaifenesin can be taken with or without food, though food may delay the time to peak concentration without affecting overall absorption 2
Dosing flexibility: The immediate-release formulation allows flexible dose titration (200-400 mg range) to adjust plasma concentrations based on symptom severity 4
Safety profile: Both formulations are well-tolerated, with gastrointestinal effects being the most common adverse events, typically mild in severity 3
Common Pitfalls to Avoid
- Do not exceed 6 doses per day with immediate-release formulations to prevent exceeding the maximum daily dose 1
- Extended-release tablets should not be crushed or chewed, as this would compromise the controlled-release mechanism 2
- Multiple daily doses are necessary with immediate-release formulations to maintain therapeutic effect throughout the day 4