Is leuprolide (Lupron) administered with enzalutamide?

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From the Research

Administration of Leuprolide with Enzalutamide

  • Leuprolide is administered with enzalutamide in the treatment of high-risk biochemically recurrent prostate cancer, as shown in the EMBARK study 1, 2, 3.
  • The combination of enzalutamide and leuprolide has been found to improve metastasis-free survival compared to leuprolide alone 1, 2.
  • The EMBARK study also explored the use of enzalutamide monotherapy, but the combination with leuprolide was found to be more effective in improving metastasis-free survival 1, 2.
  • The administration of leuprolide with enzalutamide is also supported by other studies, which suggest that the combination of androgen receptor signaling inhibitors (ARSIs) and ADT can improve outcomes in high-risk biochemically recurrent prostate cancer 4.

Rationale for Combination Therapy

  • The combination of enzalutamide and leuprolide is thought to be more effective than leuprolide alone due to the potent anti-androgen effects of enzalutamide 5.
  • The use of enzalutamide in combination with leuprolide may help to suppress or eliminate micrometastases, reducing the risk of disease progression 5.
  • The EMBARK study and other research suggest that the combination of ARSIs and ADT can improve metastasis-free survival and overall outcomes in high-risk biochemically recurrent prostate cancer 1, 2, 3, 4.

References

5
Research

Neoadjuvant Enzalutamide Prior to Prostatectomy.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2017

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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