Interpretation of Your Liver Fibrosis and Inflammation Test Results
Your FibroTest and ActiTest results are excellent, showing no evidence of liver fibrosis (F0) or inflammation (A0), with all biochemical markers within normal ranges, indicating a healthy liver with no significant disease. 1
Understanding Your Scores
Fibrosis Assessment
- Your FibroTest score of 0.11 places you firmly in the F0 category (no fibrosis), well below the 0.21 threshold that would suggest any fibrotic changes 2, 1
- This indicates no scarring or structural damage to your liver tissue according to the METAVIR classification system 2
- FibroTest has demonstrated high diagnostic accuracy with AUCs of 0.90 for detecting significant fibrosis in chronic hepatitis B, and performs better than simpler markers like APRI 2
Inflammation Assessment
- Your ActiTest score of 0.03 corresponds to A0 (no activity), indicating complete absence of hepatocellular necroinflammation 1
- This is below the 0.17 threshold for any inflammatory activity and represents optimal liver health 1
- The absence of inflammation is a positive prognostic indicator for long-term liver health 1
Your Individual Test Components
All five biochemical markers used in the FibroTest calculation are within normal ranges 1:
- Bilirubin (0.6 mg/dL): Normal liver excretory function
- GGTP (12 U/L): No evidence of biliary obstruction or alcohol-related injury
- ALT (14 U/L): Excellent—well below the upper limit, indicating no hepatocellular injury 1
- Apolipoprotein A1 (146 mg/dL): Normal liver synthetic function
- Haptoglobin (138 mg/dL): Normal acute phase reactant
- Alpha-2-Macroglobulin (1.85 g/L): Within the normal range of 1.50-3.50 g/L
Clinical Significance and Reliability
Your results are highly reliable because all quality criteria are met 2:
- Normal transaminase levels (ALT <5x upper limit of normal) ensure accurate interpretation 2
- No evidence of acute hemolysis, acute hepatitis, or extrahepatic cholestasis that could confound results 2
- All individual components are within expected ranges without isolated extreme values 2
The combination of F0 fibrosis with A0 inflammation and normal ALT represents the best possible scenario for liver health 1.
What This Means for You
No treatment or intervention is required for liver disease 3. However, appropriate monitoring depends on your underlying risk factors:
If You Have NO Risk Factors for Liver Disease
- Repeat FibroTest in 3 years for routine surveillance 2
- Standard liver function tests (ALT, AST, bilirubin) can be checked annually as part of routine health maintenance 3
If You Have Risk Factors (Viral Hepatitis, Metabolic Syndrome, Diabetes, Alcohol Use)
- Repeat FibroTest in 12 months to establish a baseline trend 2, 3
- Consider standard liver function tests at 6-month intervals 3
- Address modifiable risk factors aggressively (alcohol cessation, weight management, diabetes control) 3
Important Caveats
Be aware of situations where FibroTest interpretation may be unreliable 2:
- Acute hemolysis or Gilbert's syndrome (requires specialist consultation) 2, 3
- Acute hepatitis or severe inflammation (ALT >5x normal) 2
- Extrahepatic cholestasis or biliary obstruction 2
- Right heart failure or congestive liver disease 2
- Liver transplant recipients (test not validated in this population) 2
When to Seek Further Evaluation
Contact your physician if any of the following occur 3:
- Development of symptoms suggesting liver disease (jaundice, ascites, confusion, bleeding)
- Abnormal liver function tests on routine monitoring
- Future FibroTest scores showing progression (increase above 0.21)
- New exposure to hepatotoxic medications or substances
Bottom Line
Your liver shows no evidence of fibrosis or inflammation by this highly accurate non-invasive assessment 2, 1. FibroTest has a 91% negative predictive value for excluding significant fibrosis, making your results highly reliable for ruling out liver disease 4. Continue routine monitoring based on your individual risk profile, but no immediate action or treatment is needed 1, 3.