From the Research
Effects of Long-Term Flutamide Use on Women with PCOS
The effects of long-term Flutamide use on women with Polycystic Ovary Syndrome (PCOS) can be understood through various studies that have investigated its impact on different aspects of the syndrome.
- Lipid Profile: Studies have shown that Flutamide can improve the lipid profile in women with PCOS. For example, a study published in 1998 found that treatment with Flutamide was associated with a significant decrease in the LDL/HDL ratio, total cholesterol, LDL, and triglycerides 1. Another study published in 2004 found that Flutamide treatment decreased visceral fat, androstenedione, DHEA-S, total and low-density lipoprotein (LDL) cholesterol, and improved hirsutism 2.
- Ovulatory Function: Flutamide has been shown to have a positive effect on ovulatory function in women with PCOS. A study published in 2013 found that Flutamide therapy increased the percentage of cycles that were ovulatory and regularized the menstrual profile in PCOS patients 3.
- Hormonal Parameters: Flutamide has been found to have various effects on hormonal parameters in women with PCOS. For example, a study published in 2000 found that Flutamide restored sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone 4. Another study published in 2023 found that low-dose Flutamide reduced serum luteinizing hormone and androgen levels, and attenuated lipid accumulation in newly formed adipocytes derived from subcutaneous abdominal adipose stem cells 5.
- Abdominal Adipogenic Function: Flutamide has been found to reduce abdominal fat deposition and attenuate accelerated lipid accumulation in newly formed adipocytes derived from subcutaneous abdominal adipose stem cells in normal-weight women with PCOS 5.
Key Findings
- Flutamide improves lipid profile in women with PCOS 1, 2
- Flutamide increases ovulatory function and regularizes menstrual profile in PCOS patients 3
- Flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone 4
- Flutamide reduces abdominal fat deposition and attenuates lipid accumulation in newly formed adipocytes derived from subcutaneous abdominal adipose stem cells 5