From the Guidelines
Nugenix does not significantly increase testosterone levels based on available evidence. The efficacy and safety of testosterone treatment in men, as reported in a 2020 study by the American College of Physicians 1, highlights that testosterone treatment is primarily approved for men with primary or secondary hypogonadism caused by specific disorders, and its use in men with nonspecific symptoms and low-normal testosterone levels is not well-established. Key points to consider include:
- The study emphasizes that much of the increase in testosterone use in the United States is in men without established conditions that cause permanent testicular or hypothalamic–pituitary dysfunction, and many do not have their testosterone levels tested before starting therapy.
- The American College of Physicians' clinical practice guideline focuses on the diagnosis and treatment of hypogonism, but the evidence for supplements like Nugenix is not considered in this context.
- Ingredients in Nugenix, such as zinc, may help maintain normal testosterone levels in deficient men, but there is no strong evidence that the supplement as a whole increases testosterone levels in healthy men.
- Lifestyle factors, including regular exercise, adequate sleep, maintaining a healthy weight, and balanced nutrition, are likely to have more substantial effects on testosterone levels than over-the-counter supplements like Nugenix.
- If concerned about low testosterone, consulting a healthcare provider for a proper diagnosis and medically proven treatments is recommended, rather than relying on supplements with unproven efficacy, as supported by the American College of Physicians' guideline 1.
From the Research
Testosterone Levels and Nuegenix
- There is no direct evidence in the provided studies to suggest that Nuegenix increases testosterone levels.
- The studies focus on testosterone replacement therapy (TRT) and its effects on hypogonadal men, rather than specific supplements like Nuegenix 2, 3, 4, 5, 6.
- TRT is recommended for men with symptomatic testosterone deficiency to correct selected symptoms and induce and maintain secondary sex characteristics 3, 6.
- The decision to start TRT should be made after discussing the potential benefits and risks of therapy and involving the patient in decision making 6.
- The studies do not provide information on the effectiveness of Nuegenix or similar supplements in increasing testosterone levels.
Testosterone Replacement Therapy
- TRT can improve sexual function, depressive symptoms, bone density, and lean body mass in hypogonadal men 3, 5.
- The evidence is conflicting regarding the effect of TRT on cardiovascular events and mortality 3, 4.
- Clinicians should monitor men receiving TRT for symptom improvement, potential adverse effects, and adherence 3, 6.
- Serum testosterone, hematocrit, and prostate-specific antigen levels should be measured at baseline and at least annually in men 40 years or older receiving TRT 3, 6.