Brand Name for Telmisartan/Amlodipine Combination
The telmisartan/amlodipine fixed-dose combination is marketed under the brand name Twynsta in the United States and European Union. 1
Available Formulations
The single-pill combination is available in multiple dose strengths to allow for flexible dosing based on blood pressure control needs:
- Telmisartan 40 mg / Amlodipine 5 mg 1, 2
- Telmisartan 80 mg / Amlodipine 5 mg 1
- Telmisartan 40 mg / Amlodipine 10 mg 1
- Telmisartan 80 mg / Amlodipine 10 mg 1, 3
Clinical Indications
This combination is FDA-approved for:
- Replacement therapy in patients already taking separate telmisartan and amlodipine tablets 1
- Add-on therapy for patients not achieving blood pressure goals with amlodipine monotherapy 1
- Add-on therapy for patients not achieving blood pressure goals with telmisartan or another angiotensin II receptor antagonist monotherapy 1
- Initial therapy in patients likely to require multiple drugs to achieve blood pressure goals 1
Dosing Considerations
- The combination is administered once daily, regardless of whether taken in the morning or evening 2
- The highest dose combination (telmisartan 80 mg / amlodipine 10 mg) provides the greatest blood pressure reductions 3
- Efficacy is consistent across patient subgroups including elderly, diabetic, obese, and those with renal impairment 3