How to manage mesenteric jejunal diverticulitis?

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Last updated: November 20, 2025View editorial policy

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Management of Jejunal Diverticulitis Found at Laparotomy

A. Resection and anastomosis is the correct answer—intestinal resection with primary anastomosis is the best surgical option for jejunal diverticulitis in stable patients. 1

Rationale for Resection and Anastomosis

Surgery is the preferred treatment for jejuno-ileal diverticulitis because of the high mortality and morbidity related to the severity of the disease. 1 Once you have already performed a laparotomy and confirmed mesenteric jejunal diverticulitis, the appropriate definitive management is resection with primary anastomosis rather than simply taking a biopsy.

Key Management Principles

  • Intestinal resection with anastomosis is the best surgical option in hemodynamically stable patients with jejunal diverticulitis who have already undergone laparotomy. 1

  • The high mortality rate associated with jejunal diverticulitis (particularly when complicated) necessitates definitive surgical treatment rather than conservative measures once the abdomen is open. 2, 3

  • Biopsy alone would be inadequate because it does not address the source of infection or prevent progression to perforation and peritonitis. 4

Clinical Decision Algorithm

For stable patients:

  • Perform segmental jejunal resection with end-to-end primary anastomosis. 2, 4
  • This approach provides definitive treatment and excellent outcomes when performed promptly. 4

For unstable patients with shock or generalized fecal peritonitis:

  • Consider intestinal resection with stoma creation instead of primary anastomosis to minimize operative time and avoid poor outcomes. 1
  • This damage control approach is reserved for hemodynamically unstable patients or those with significant physiological derangement. 5

Why Not Biopsy?

  • Biopsy does not provide source control for the infection. 1
  • Jejunal diverticulitis carries risk of imminent perforation and acute peritonitis, requiring definitive surgical management. 4
  • The diagnosis is typically confirmed by imaging preoperatively or by direct visualization at laparotomy—histopathologic confirmation via biopsy is not necessary for management decisions. 2, 4

Common Pitfalls to Avoid

  • Do not underestimate the severity: Jejunal diverticulitis has higher complication rates than colonic diverticulitis and requires aggressive surgical management. 3
  • Do not delay definitive surgery: Once laparotomy is performed and diverticulitis is confirmed, proceeding with resection prevents progression to life-threatening complications. 2, 4
  • Assess hemodynamic stability carefully: The choice between primary anastomosis versus resection with stoma depends critically on patient stability and presence of fecal peritonitis. 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Ruptured Diverticula

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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