What is the Monarch eTNS (external Trigeminal Nerve Stimulation) system?

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Last updated: April 1, 2025View editorial policy

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From the Research

The Monarch eTNS system is a promising treatment option for epilepsy, with studies showing it can reduce seizure frequency by up to 64% and improve quality of life scores in patients with drug-resistant epilepsy. The system works by delivering mild electrical stimulation to the trigeminal nerve, which is thought to modulate brain activity in regions involved in seizure regulation.

Key Benefits

  • Reduces seizure frequency by up to 64% in patients with drug-resistant epilepsy 1
  • Improves quality of life scores in patients with epilepsy 1, 2
  • Can reduce seizure severity scores and improve responder rates (seizure reduction ≥50%) 1, 2
  • Mild side effects, including headache, ear pain, and skin irritation at the application site 1, 2, 3

Important Considerations

  • The Monarch eTNS system is a non-invasive treatment option, which is particularly interesting because it does not require surgery and is instantaneously removable 1
  • Treatment protocols may vary, and stimulation parameters, such as frequency and intensity, may need to be adjusted according to patient preferences and tolerance 1, 2, 3
  • Multicenter randomized double-blind clinical trials with standardized stimulation protocols and long-term follow-up studies are necessary to finally assess the treatment outcome of the Monarch eTNS system in drug-resistant epilepsies 1

Clinical Use

  • The Monarch eTNS system may be particularly useful for patients with epilepsy who have not responded to traditional treatments or who are seeking non-medication alternatives 4
  • A prescription from a healthcare provider is required, and insurance coverage may vary 4
  • Patients with implanted medical devices or certain neurological conditions may not be suitable for the Monarch eTNS system 4

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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