Augmentin IV Dosing for Pediatric Patients
Recommended Dosage
For pediatric patients requiring intravenous Augmentin (amoxicillin/clavulanate), the standard dosage is 100-200 mg/kg/day of the amoxicillin component, divided into 3-4 doses administered every 6-8 hours. 1
Specific Dosing Parameters
- Standard dose range: 100-200 mg/kg/day divided into 3-4 doses 1
- Administration: Given by short IV infusion 1
- Frequency: Every 6-8 hours (3-4 times daily) 1
- Maximum daily dose: Up to 4000 mg (4 g) per day of the amoxicillin component for severe infections 2
Dosing by Severity
For mild to moderate infections:
For severe infections or high-resistance areas:
- Use higher dosing up to 200 mg/kg/day 1
- Consider maximum dosing of 90 mg/kg/day for oral formulations when transitioning from IV 2
Clinical Efficacy Data
The evidence demonstrates excellent outcomes with IV Augmentin in pediatric populations:
- Complete clinical cure or distinct improvement was achieved in 100% of assessable cases in a study of 58 children (mean age 6 years) with lower respiratory tract infections 1
- Bacteriological success was obtained in 92% of assessable cases 1
- The formulation was well-tolerated with minimal adverse effects 1
Important Clinical Considerations
Administration Guidelines
- Administer by short IV infusion, not as a bolus 1
- Most patients in clinical trials were hospitalized for lower respiratory tract infections 1
- The dosage range of 100-200 mg/kg/day has been validated in children aged 1-15 years 1
Transition to Oral Therapy
When transitioning from IV to oral Augmentin:
- For respiratory infections: 45 mg/kg/day in 2 doses for mild-moderate infections 2
- For severe infections or high pneumococcal resistance: 90 mg/kg/day in 2 doses 2
- Treatment duration typically 7-10 days for respiratory infections 2