From the Research
Effectiveness of Nexplanon with GLP-1 Medications
- There is no direct evidence to suggest that the effectiveness of Nexplanon (etonogestrel) decreases with GLP-1 (Glucagon-like peptide-1) medications 1, 2.
- Studies have investigated the effects of GLP-1 analogs on oral contraceptives, but not specifically on Nexplanon 3.
- One study found that semaglutide, a once-weekly human GLP-1 analog, did not reduce the bioavailability of a combined oral contraceptive, ethinylestradiol/levonorgestrel 3.
- Other studies have explored the use of GLP-1 receptor agonists for the treatment of polycystic ovary syndrome (PCOS) and their effects on insulin sensitivity, weight loss, and cardiovascular disease risk 4, 5.
- However, there is no specific research on the interaction between GLP-1 medications and Nexplanon, a long-term reversible contraception method 1.
GLP-1 Medications and Contraceptives
- GLP-1 receptor agonists have been shown to improve insulin sensitivity, reduce cardiovascular disease risk, and result in weight loss, making them a potential treatment option for PCOS 4.
- The effects of GLP-1 medications on contraceptives are not well understood, and more research is needed to determine their impact on the effectiveness of Nexplanon 3.
- The available evidence suggests that GLP-1 analogs may not affect the bioavailability of oral contraceptives, but this may not be generalizable to all types of contraceptives, including Nexplanon 3.
Limitations of Current Research
- The current research on GLP-1 medications and contraceptives is limited, and more studies are needed to fully understand their interaction 1, 2, 3, 4, 5.
- The available evidence is based on studies of oral contraceptives, and it is unclear whether the results can be applied to other types of contraceptives, such as Nexplanon 3.