From the Research
Timeframe for Decrease in Inflammatory Markers
The expected timeframe for a decrease in inflammatory markers after initiating prednisone (corticosteroid) therapy can vary depending on the specific marker and the condition being treated.
- Studies have shown that prednisone can lead to a significant decrease in inflammatory markers such as C-reactive protein (CRP) within 3 days of treatment 1.
- Another study found that IL-6 levels decreased significantly after 2 days of prednisone treatment, with maximal and stable anti-inflammatory effects from the beginning of treatment 2.
- A study on polymyalgia rheumatica patients treated with modified-release prednisone found significant decreases in IL-6 and CRP levels after 1 month of treatment, with 76.7% of patients having IL-6 levels at or below the upper normal limit 3.
- Acute serum protein and cytokine response to a single dose of prednisone in adult volunteers showed significant declines in adrenal steroids by 3 hours after dosing, and down-regulation of inflammatory serum proteins by 6 hours 4.
- A study on chronic rhinosinusitis patients treated with systemic prednisone found a statistically significant decrease in periostin, eotaxin, and IgE expression in plasma after 1 week of treatment 5.
Inflammatory Markers Affected by Prednisone
The inflammatory markers affected by prednisone treatment include: