What could be causing my pain?

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Last updated: November 22, 2025View editorial policy

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What Could Be Causing Your Pain?

Your pain requires immediate systematic evaluation to exclude life-threatening conditions first, then identify the specific cause based on location, character, timing, and associated symptoms.

Critical Life-Threatening Causes to Rule Out First

You need urgent evaluation if your pain has any of these features:

  • Chest pain with shortness of breath, rapid heart rate - Could indicate pulmonary embolism, which presents with dyspnea, pleuritic chest pain, tachycardia, and tachypnea 1
  • Sudden "ripping" chest pain radiating to the back - Suggests aortic dissection, with pulse differences between arms in 30% of cases 1
  • Sharp chest pain that improves sitting forward, worsens lying down - May indicate pericarditis, which shows widespread ST-elevation with PR depression on ECG 1
  • Chest pain with fever, productive cough - Could be pneumonia with pleuritic pain, regional dullness to percussion, and possible friction rub 1
  • Sudden chest pain with absent breath sounds on one side - Classic for pneumothorax, characterized by dyspnea, pleuritic pain, and hyperresonant percussion 1

A critical pitfall: 13% of patients with sharp, pleuritic chest pain actually have acute myocardial ischemia, and 7% of patients with reproducible chest wall tenderness have acute coronary syndrome 1, 2. Never assume sharp pain or tenderness on palpation excludes cardiac disease.

Common Non-Life-Threatening Causes

Musculoskeletal Pain (Most Common)

  • Costochondritis/Tietze syndrome - Tenderness of the costochondral joints on palpation, inflammation of cartilage connecting ribs to sternum 3, 4
  • Muscle strain or spasm - Particularly pectoral muscles, worsens with movement 3, 4
  • Rib fracture - Most common in ribs 3-8, presents with localized pain worsening with breathing or palpation 4
  • Nerve entrapment - Especially the lateral cutaneous branch of the third intercostal nerve 3, 4

Breast Pain (If Female)

  • Cyclical mastalgia - Bilateral, diffuse, related to menstrual cycle, affects women in their 30s, spontaneous resolution in 14-20% within 3 months 3
  • Noncyclical mastalgia - Unilateral, focal, precisely localizable, more common in women in their 40s, inflammatory rather than hormonal 3
  • Mastitis or breast abscess - Focal pain preceding induration, redness, warmth, and fever 3

Gastrointestinal Causes

  • Gastroesophageal reflux, peptic ulcer disease, esophageal disorders - Account for 10-20% of chest pain in outpatients 4
  • Gallbladder pathology - Can refer pain to chest area 3

Other Causes

  • Herpes zoster - Dermatomal distribution pain triggered by touch, with characteristic unilateral rash 1
  • Fibromyalgia or fibromyositis - Widespread musculoskeletal pain 3

Essential Initial Evaluation

You need these tests immediately if presenting with acute pain:

  • ECG within 10 minutes - To identify STEMI, pericarditis patterns, or pulmonary embolism signs 1
  • Chest X-ray - To evaluate for pneumothorax, pneumonia, pleural effusion, or widened mediastinum 1
  • Cardiac troponin - Measured as soon as possible to exclude myocardial injury 1

Specific Features That Guide Diagnosis

Pain Character

  • Sharp, stabbing, "knifelike" worsening with breathing - Pleuritic pain from pleural inflammation, pneumonia, or pulmonary embolism 1, 2
  • Pressure or heaviness - More typical of anginal pain from coronary artery disease 2
  • Creaking leather sound with breathing - Pleural friction rub indicating pleural inflammation 2

Pain Location

  • Subareolar or nipple area, lower inner breast - Noncyclical mastalgia requiring evaluation to exclude breast lesion 3
  • Lateral rib area - Rib fracture, costochondritis, or nerve entrapment 4
  • Reproducible with chest wall palpation - Suggests musculoskeletal origin but does NOT exclude serious pathology 1

Associated Symptoms

  • Fever - Pneumonia, mastitis, or pericarditis 1
  • Shortness of breath - Pulmonary embolism, pneumothorax, or heart failure 1
  • Redness, warmth, swelling - Mastitis or cellulitis 3

Immediate Action Required

Seek emergency care immediately if you have:

  • Chest pain with shortness of breath, rapid heart rate, or sweating 1
  • Sudden severe chest pain radiating to back 1
  • Chest pain with weakness, slurred speech, or facial swelling 5
  • Chest pain with fever and productive cough 1

Pain Management While Determining Cause

For non-emergent musculoskeletal pain:

  • Ibuprofen - Use at lowest effective dose for shortest time needed; avoid if history of ulcers, bleeding problems, or heart disease 5
  • Acetaminophen - Stop and seek medical attention if pain worsens or lasts more than 10 days 6

Critical warning: Do not use pain relief as a diagnostic test. Nitroglycerin response does not confirm or exclude myocardial ischemia 1.

References

Guideline

Pleuritic Chest Pain Diagnosis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Pleuritic Chest Pain Characteristics and Diagnosis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Lateral Rib Pain Causes and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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