Pedicloryl (Triclofos) Dosage
The recommended dosage of Pedicloryl (triclofos) for pediatric sedation is 80 mg/kg administered orally, with an additional 5 mg/kg every 5 minutes if needed, up to a maximum observation period of 60 minutes from initial administration. 1
Standard Dosing Protocol
- Initial dose: 80 mg/kg orally 1
- Onset of action: Median 25 minutes (range 20-30 minutes) 1
- Additional dosing: If inadequate sedation after 30 minutes, administer 5 mg/kg every 5 minutes until 60 minutes from initial dose 1
- Failure threshold: If Ramsay sedation score remains ≤4 after 60 minutes, the procedure is considered a failure and general anesthesia should be considered 1
Clinical Evidence
The dosing recommendation is based on a prospective observational study of 73 children (mean age 23.4 months, mean weight 12 kg) undergoing ophthalmic examination for pediatric glaucoma. 1 The mean effective dose used was 83.8 mg/kg, with successful completion of examination in 64 children (87.7% success rate). 1
Safety Profile
- Cardiovascular monitoring: Heart rate and arterial oxygen saturation should be measured throughout the sedation period 1
- Adverse events: No major side effects were reported in the clinical study 1
- Age limitation: This dosing has been validated in children less than 5 years of age 1
Important Clinical Considerations
Note: Pedicloryl is the brand name for triclofos, a sedative-hypnotic agent. This should not be confused with chlorpheniramine (an antihistamine) or other similarly named medications. The evidence specifically supports this dosing regimen for procedural sedation in young children undergoing ophthalmic examinations. 1