What is the difference between a skin abscess and cellulitis (infection of the skin and subcutaneous tissue)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 1, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Skin Abscess vs Cellulitis

When considering a differential diagnosis for a patient presenting with symptoms that could indicate either a skin abscess or cellulitis, it's crucial to approach the diagnosis systematically. The following categories help in organizing the thought process:

  • Single Most Likely Diagnosis
    • Cellulitis: This is often the first consideration due to its higher prevalence and the fact that it can sometimes be difficult to distinguish from an abscess without imaging or drainage. Cellulitis is an infection of the skin and subcutaneous tissues, usually caused by bacteria, and can present with redness, warmth, swelling, and pain in the affected area.
  • Other Likely Diagnoses
    • Skin Abscess: A localized collection of pus in the skin, often caused by bacterial infection. It typically presents as a painful, swollen, and red lump. The presence of fluctuance (a wavy feeling when pressing on the skin) can help differentiate it from cellulitis.
    • Folliculitis: An infection of the hair follicles, which can sometimes resemble the early stages of an abscess or cellulitis. It's usually less severe and can be caused by bacterial, viral, or fungal infections.
    • Furuncle (Boil): A deeper infection of the hair follicle, which can resemble a small abscess. It's typically caused by Staphylococcus aureus.
  • Do Not Miss Diagnoses
    • Necrotizing Fasciitis: A severe infection that destroys the tissue under the skin, including fat and the tissue covering the muscles (fascia). It's a medical emergency and can be life-threatening if not promptly treated. Early signs can be similar to cellulitis but progress rapidly.
    • Gas Gangrene: A potentially deadly condition caused by Clostridium perfringens, characterized by infection of the muscle tissue, leading to gas production and tissue death. It can start similarly to cellulitis but is distinguished by its rapid progression and the presence of gas in the tissues.
  • Rare Diagnoses
    • Erysipelas: A type of skin infection that involves the upper dermis, typically caused by Streptococcus bacteria. It presents with well-demarcated, raised, and shiny lesions, usually on the face or legs.
    • Actinomycosis: A chronic bacterial infection that can cause abscesses or lesions in the skin, among other symptoms. It's rare and usually associated with poor dental hygiene, immunocompromised states, or the use of intrauterine devices (IUDs).
    • Mycobacterial Infections: Such as those caused by Mycobacterium tuberculosis or atypical mycobacteria, which can cause skin lesions or abscesses, especially in immunocompromised individuals.

Each diagnosis has distinct clinical features, and a thorough history, physical examination, and sometimes imaging or laboratory tests are necessary to differentiate between them accurately.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.