From the FDA Drug Label
DOSAGE AND ADMINISTRATION • Patients new to methylphenidate: Recommended starting dose is 5 mg once daily for pediatric patients and 10 mg once daily for adults with or without food in the morning ( 2.2). • Patients currently on methylphenidate: Dexmethylphenidate hydrochloride extended-release capsules dosage is half (1/2) the current total daily dosage of methylphenidate ( 2. 2). • Patients currently on dexmethylphenidate hydrochloride immediate-release tablets: Give the same daily dose of dexmethylphenidate hydrochloride extended-release capsules ( 2.2). • Titrate weekly in increments of 5 mg in pediatric patients and 10 mg in adult patients ( 2.2). • Maximum recommended daily dose: 30 mg in pediatric patients and 40 mg in adults ( 2. 2).
The recommended dosing for Focalin (dexmethylphenidate) is as follows:
- Starting dose: 5 mg once daily for pediatric patients and 10 mg once daily for adults
- Titration: Increase dose weekly in increments of 5 mg for pediatric patients and 10 mg for adult patients
- Maximum dose: 30 mg daily for pediatric patients and 40 mg daily for adults
- Administration: Capsules may be swallowed whole or opened and sprinkled on applesauce 1
From the Research
Focalin (dexmethylphenidate) dosing should be individualized based on the patient's needs and response, with careful consideration of potential side effects and safety signals, as highlighted in the most recent study 2. For children (6 years and older), start with 2.5 mg twice daily, at least 4 hours apart, typically in the morning and early afternoon. The dose can be gradually increased by 2.5 to 5 mg weekly, not exceeding 20 mg daily (10 mg twice daily). For adults, begin with 2.5 mg twice daily, potentially increasing to 10 mg twice daily. Focalin XR (extended-release) is taken once daily in the morning, starting at 5 mg for children or 10 mg for adults, with possible weekly adjustments up to 20 mg daily for children and 40 mg daily for adults. Take immediate-release tablets with or without food, and swallow extended-release capsules whole or sprinkle contents on applesauce. Dosing requires careful monitoring for effectiveness and side effects like increased heart rate, blood pressure, or appetite suppression, as well as potential safety signals such as myocardial infarction, coronary artery dissection, and suicidal ideation, as reported in the study 2. The medication works by increasing dopamine and norepinephrine levels in the brain, improving focus and attention in ADHD patients. Key considerations in dosing Focalin include:
- Starting with a low dose and gradually increasing as needed and tolerated
- Monitoring for side effects and adjusting the dose accordingly
- Being aware of potential safety signals and taking steps to mitigate risks
- Individualizing the dose based on the patient's response and needs, as emphasized in the study 3. It is essential to weigh the benefits of Focalin against the potential risks and to carefully monitor patients for any adverse effects, particularly in light of the findings from the study 2.