What is the management of acute ankle sprain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: November 23, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Management of Acute Ankle Sprain

Immediate Treatment: PRICE Protocol

Implement the PRICE protocol (Protection, Rest, Ice, Compression, Elevation) immediately for all acute ankle sprains, combined with semirigid bracing rather than elastic bandages or tape. 1

PRICE Components:

  • Protection: Apply a semirigid ankle brace or lace-up support immediately—this is superior to elastic bandages or tape and provides the most cost-effective treatment 1, 2
  • Rest: Limit weight-bearing for 3-5 days only, avoiding activities that cause pain 1, 3
  • Ice: Apply cold (ice and water surrounded by damp cloth) for 20-30 minutes per session without direct skin contact to prevent cold injury 1
  • Compression: Use compression wraps for comfort while ensuring circulation is not compromised 1
  • Elevation: Keep ankle above heart level 3

Pain Management:

  • NSAIDs (piroxicam, celecoxib, or naproxen) should be used to reduce pain and swelling, which accelerates return to activity 4, 3
  • Heat application is contraindicated in acute ankle injuries 1, 3

Early Mobilization: 48-72 Hours Post-Injury

Begin supervised exercise therapy within 48-72 hours after injury—this has Level 1 evidence as the most effective treatment for ankle sprain rehabilitation. 1, 2

Exercise Protocol Must Include:

  • Range of motion exercises 1
  • Progressive strengthening exercises 1, 3
  • Proprioception training (balance exercises) 1, 2
  • Coordination exercises 2
  • Sport-specific functional exercises as recovery progresses 5

Supervised exercises are superior to non-supervised training and should focus on proprioception, strength, coordination, and function. 2

Avoid Prolonged Immobilization

Functional treatment with bracing is strongly preferred over immobilization or casting. 1, 2

Evidence for Functional Treatment:

  • Returns patients to sports 4.6 days sooner than immobilization 1, 2
  • Returns patients to work 7.1 days sooner than immobilization 1, 2
  • Immobilization shows no benefits compared to functional treatment 1, 2

Follow-Up Assessment

Re-examine the patient 3-5 days after injury when pain and swelling have improved for accurate diagnosis and treatment planning. 1, 2

  • Clinical assessment of ligament damage is optimized at 4-5 days post-injury when swelling has decreased 1, 2
  • Use Ottawa Ankle Rules to determine if radiography is needed—this reduces unnecessary X-rays by approximately 60% 2

Prevention of Recurrent Sprains

Continue wearing a semirigid ankle brace throughout rehabilitation and upon return to sport—this has Level 1 evidence for preventing recurrent sprains. 3, 2

  • Bracing is superior to taping and neuromuscular training alone for preventing recurrence 2
  • Incorporate proprioceptive exercises into regular training activities for patients with history of recurrent sprains 1, 2

Special Consideration: High Ankle Sprains

High ankle (syndesmotic) sprains require more intensive rehabilitation and significantly longer recovery time than lateral ankle sprains. 1, 3

Diagnosis:

  • Mechanism: dorsiflexion with external rotation or eversion with internal rotation 3
  • Pain location: syndesmosis area between tibia and fibula, above typical lateral ligament injury site 3
  • Use crossed-leg test (squeeze test): pressure on medial knee with legs crossed produces syndesmosis pain 1, 3

Treatment:

  • Same PRICE protocol with semirigid bracing 3
  • More intensive supervised rehabilitation 3
  • Continue bracing throughout recovery and return to sport 3

Critical Pitfalls to Avoid

  • Excessive imaging: Use Ottawa Ankle Rules to guide radiography decisions 2, 5
  • Unwarranted non-weight-bearing beyond 3-5 days: Early mobilization is essential 5
  • Unjustified immobilization: Functional treatment is superior 5
  • Delay in functional movements: Exercise should begin within 48-72 hours 1, 5
  • Inadequate rehabilitation: This leads to chronic pain, decreased range of motion, and joint instability 1, 2

References

Guideline

Ankle Sprain Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Rehabilitation Guidelines for High Ankle Sprains

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

High Ankle Sprain Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.