What is the maximum recommended daily dose of oral Robaxin (methocarbamol)?

Maximum Daily Dose of Oral Robaxin (Methocarbamol)

The maximum recommended daily dose of oral Robaxin (methocarbamol) is 8 grams (8,000 mg) per day for severe conditions during the first 48-72 hours of treatment, after which the dose should be reduced to approximately 4 grams per day for maintenance. 1

Initial Dosing (First 48-72 Hours)

• Standard initial dose: 6 grams per day is recommended for the first 48-72 hours of treatment 1
• For severe conditions: up to 8 grams per day may be administered during this initial period 1
• This can be achieved with either:
  • 500 mg tablets: 3 tablets four times daily (6 g/day) 1
  • 750 mg tablets: 2 tablets four times daily (6 g/day) 1

Maintenance Dosing (After 72 Hours)

• Reduce to approximately 4 grams per day after the initial 48-72 hour period 1
• Maintenance regimens include:
  • 500 mg tablets: 2 tablets four times daily 1
  • 750 mg tablets: 1 tablet every 4 hours or 2 tablets three times daily 1

Critical Safety Considerations

• Avoid alcohol consumption entirely while taking methocarbamol, as the combination can cause fatal central nervous system depression due to synergistic sedative-hypnotic effects 2
• Therapeutic blood concentrations are reported as 24-41 micrograms/mL; toxic levels significantly exceed this range 2
• The 8-gram maximum should only be used for severe conditions and only during the initial treatment phase—prolonged use at this dose is not recommended 1