Does BMP (Bone Morphogenetic Protein) contain EGF (Epidermal Growth Factor)?

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Does BMP Contain eGFR?

No, BMP (Basic Metabolic Panel) does not contain eGFR (estimated Glomerular Filtration Rate) as a standard component, though eGFR is typically calculated and reported automatically when a BMP is ordered because the panel includes serum creatinine.

Understanding the BMP Components

The question appears to be asking about laboratory testing rather than Bone Morphogenetic Protein, which is the focus of the provided evidence. Based on standard clinical practice:

  • The Basic Metabolic Panel (BMP) is a blood test that measures 8 components: sodium, potassium, chloride, bicarbonate (CO2), blood urea nitrogen (BUN), creatinine, glucose, and calcium.

  • eGFR is not directly measured but is automatically calculated by the laboratory using the serum creatinine value from the BMP, along with patient age, sex, and race using equations such as the CKD-EPI formula.

  • Most laboratories report eGFR alongside BMP results as a reflex test whenever creatinine is measured, making it appear as part of the panel even though it's a calculated value rather than a measured component.

Clinical Relevance

  • When you order a BMP, you will receive an eGFR value on the same report, but this is due to automatic calculation protocols rather than eGFR being an intrinsic component of the panel itself.

  • The distinction matters for understanding what is actually being measured versus calculated, though for practical clinical purposes, ordering a BMP effectively provides you with kidney function assessment through both creatinine and eGFR.


Note: The provided evidence focuses on Bone Morphogenetic Protein (BMP) in the context of bone regeneration and growth factors 1, 2, 3, which is unrelated to the Basic Metabolic Panel laboratory test. If your question was indeed about Bone Morphogenetic Protein and Epidermal Growth Factor (EGF), these are distinct growth factor families that can interact through signaling pathways 4, 5, 6 but BMP does not "contain" EGF as they are separate molecular entities.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Bone Morphogenic Protein 2's Role in Osteoblast and Osteoclast Differentiation

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Bone morphogenetic proteins.

Growth factors (Chur, Switzerland), 2004

Research

Convergence of the BMP and EGF signaling pathways on Smad1 in the regulation of chondrogenesis.

The International journal of developmental biology, 1999

Research

Cross-talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification.

Developmental dynamics : an official publication of the American Association of Anatomists, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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