Clarification: The Question Refers to Donepezil (Aricept)
Based on the context of your question, you are asking about donepezil (Aricept), which is prescribed at 10 mg daily for Alzheimer's disease. 1, 2
Standard Donepezil Dosing
Donepezil should be taken as 10 mg once daily, not twice daily, and the American Geriatrics Society recommends taking it in the morning rather than at bedtime to minimize sleep disturbances. 2
Key Dosing Details:
- Initial dose: 5 mg once daily 1, 2
- Target dose: 10 mg once daily after 4-6 weeks if needed 1
- Timing: Morning administration is preferred over bedtime to reduce sleep disturbances 2
- Administration: Can be taken with or without food 1
Important Considerations
Dose-Dependent Side Effects:
The 10 mg dose carries higher risk of gastrointestinal adverse effects compared to 5 mg: 2
- Nausea/vomiting (relative risk 2.54)
- Diarrhea (relative risk 2.57)
- Anorexia (relative risk 3.21)
- Dizziness (relative risk 1.47)
- Muscle cramps, particularly leg cramps
Timing of Side Effects:
- 70-80% of gastrointestinal side effects occur within the first 2 weeks 2
- 60-65% of these effects resolve within the first month 2
Clinical Recommendation
If you are currently taking 10 mg at bedtime, consider switching to morning administration to improve sleep quality and potentially enhance medication effectiveness. 2 Monitor for gastrointestinal symptoms, particularly during the first month of treatment. 2