From the Research
Dosing Information for Calcitriol (Rocaltrol) in Children
The dosing of Calcitriol (Rocaltrol) for a 2-year-old child weighing 12kg can be considered based on the available evidence:
- According to the study 1, for patients less than 30 kg, the dose of calcitriol is 3 micrograms per dose, administered twice a week.
- The study 2 provides information on the initial doses of intravenous calcitriol for pediatric end-stage renal disease patients on hemodialysis, which were 0.5-1.5 microg, but this is for a different administration route and patient population.
- The study 3 suggests a dose of 40 ng/kg/day calcitriol for X-linked hypophosphatemia, but this is a different condition and dosing regimen.
- The study 4 mentions calcitriol doses for patients with pseudohypoparathyroidism, with some patients requiring doses ≥ 1.5 mcg/day, but this is also a different condition.
Relevant Dosing Regimen
Based on the study 1, which provides dosing information for children with renal osteodystrophy, the dose for a 2-year-old child weighing 12kg would be:
- 3 micrograms per dose, administered twice a week, as the child weighs less than 30 kg.