From the Research
Dosage Information
- The appropriate dose of Racecadotril for a 2-year-old child weighing 12 kilograms can be determined based on the studies that have investigated the use of Racecadotril in children.
- According to the study by 1, the dose of Racecadotril used in infants aged 3 months to 4 years was 1.5 mg/kg administered orally 3 times daily.
- Similarly, the study by 2 used a dose of 1.5 mg per kilogram of body weight orally every eight hours in boys 3 to 35 months of age.
- Based on this information, the appropriate dose of Racecadotril for a 2-year-old child weighing 12 kilograms would be 1.5 mg/kg x 12 kg = 18 mg, administered orally 3 times daily.
Administration and Safety
- The studies have shown that Racecadotril is generally well-tolerated in children, with few adverse events reported 1, 2, 3.
- The drug has been shown to be effective in reducing stool output and duration of diarrhea in children with acute watery diarrhea 1, 2.
- However, the study by 3 found that Racecadotril had no impact on the number of stools at 48 hours, the duration of hospital stay, or the duration of diarrhea in children admitted with severe gastroenteritis.
- The study by 4 also found that the current evidence does not support the routine use of Racecadotril in the management of acute diarrhea in children under five years of age outside of the context of placebo-controlled RCTs.
- The study by 5 recommends the use of Racecadotril as an adjuvant antidiarrheal treatment, with a good safety profile and potential health care savings.