Normal Dose of Trelegy for COPD
The normal dose of Trelegy for COPD is one inhalation of fluticasone furoate 100 mcg/umeclidinium 62.5 mcg/vilanterol 25 mcg once daily. 1
Dosing Specifications
- Single daily inhalation: Trelegy is administered as one actuation once daily by oral inhalation 1
- Timing consistency: The medication should be used at the same time every day 1
- Maximum frequency: Do not use more than once every 24 hours 1
Post-Inhalation Care
- Mouth rinsing required: After inhalation, rinse mouth with water without swallowing to reduce the risk of oropharyngeal candidiasis 1
Rescue Medication Use
- For breakthrough symptoms: If shortness of breath occurs between doses, use an inhaled short-acting beta2-agonist (such as albuterol) for immediate relief 1
- Not for acute relief: Trelegy is NOT indicated for relief of acute bronchospasm 1
Clinical Context for Triple Therapy
Appropriate patient selection is critical for Trelegy use:
- Indication: Reserved for patients with persistent moderate to severe dyspnea despite dual therapy, or those at high risk of COPD exacerbations 2, 3
- Disease severity: Recommended for patients in GOLD categories C and D with severe airflow obstruction (FEV₁ <50% predicted) and frequent exacerbations 4
Common Pitfall to Avoid
Never add additional inhaled corticosteroids (such as Pulmicort) to Trelegy, as this represents irrational polypharmacy and unnecessarily increases pneumonia risk 4. Trelegy already contains a complete triple therapy regimen with an inhaled corticosteroid component 1, 5.