Which of the following is a phase 1 reaction in metabolism: Acetylation, Sulfation, Glucuronidation, Methylation?

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From the Research

Phase 1 Reactions in Metabolism

  • None of the options provided (Acetylation, Sulfation, Glucuronidation, Methylation) are classified as phase 1 reactions in metabolism, according to the studies 1, 2

Phase 2 Reactions in Metabolism

  • The following are classified as phase 2 reactions in metabolism:
    • Glucuronidation 1, 3, 2, 4, 5
    • Sulfation 1, 2, 4, 5
    • Methylation 1, 2, 4
    • Acetylation 1, 2, 4

Classification of Metabolic Reactions

  • Phase 1 metabolic reactions include oxidation, reduction, and hydrolysis 1, 2
  • Phase 2 metabolic reactions are broadly defined as conjugation reactions 2

References

1
Research

[Mechanisms of drug metabolism--implications for drug interaction].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000

2
Research

Mammalian drug metabolism.

Journal of natural products, 1983

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