What is the hallmark clinical sign of intussusception in an infant?

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Hallmark Clinical Sign of Intussusception in Infants

The hallmark clinical sign of intussusception in an infant is sudden, loud crying with drawing up of the knees to the chest (Option C), representing the characteristic intermittent, crampy abdominal pain that occurs with this condition.

Classic Clinical Presentation

The most distinctive feature of intussusception is intermittent, colicky abdominal pain that manifests as sudden episodes of intense crying with the infant drawing their knees up to the chest, followed by periods of relative calm between episodes 1, 2. This intermittent pattern reflects the telescoping bowel causing episodic obstruction and pain 2.

  • Most patients present with this intermittent abdominal pain as the primary symptom 2
  • The pain episodes are crampy in nature and may progress to bloody stools and lethargy 1
  • This presentation is unusual in the first 3 months of life, with peak incidence between 3 months to 5 years 1, 2

Why Other Options Are Not the Hallmark

Option A (Rigid, board-like abdomen): This finding suggests peritonitis from perforation, which is a late complication rather than a hallmark presenting sign 2.

Option B (Vomiting green bile): While bilious vomiting can occur with intussusception as obstruction progresses, it is not the hallmark sign and occurs later in the disease course 3, 2. Nonbilious emesis is actually more common initially 2.

Option D (Sausage-shaped mass in lower left quadrant): While a palpable sausage-shaped abdominal mass is part of the classic triad, it is found in only a minority of cases and is not consistently present 2, 4. The location is also typically in the right upper quadrant, not the left lower quadrant 4.

The Classic Triad (Rarely Complete)

The traditional triad of intussusception includes 2, 5:

  • Intermittent abdominal pain (most common)
  • Currant jelly stools (bloody stools - occurs later)
  • Sausage-shaped abdominal mass (inconsistently present)

However, this complete triad is uncommon in actual clinical practice 2. The intermittent crying with knee drawing remains the most consistent early finding.

Critical Atypical Presentations

Lethargy should be considered a fifth cardinal symptom and may be a significant presenting feature, especially in younger infants who cannot communicate pain effectively 5. Altered mental status can occur even without obvious abdominal findings 2, 5.

Diagnostic Approach

  • Ultrasound is the diagnostic modality of choice, with sensitivity of 97.9% and specificity of 97.8% 6
  • Plain radiography has poor sensitivity (48%) and should not be relied upon to rule out intussusception 6
  • The characteristic ultrasound findings include the "target sign" or "doughnut sign" 4, 7

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

High risk and low incidence diseases: Pediatric intussusception.

The American journal of emergency medicine, 2025

Guideline

Differential Diagnosis for Newborn with Bilious Vomiting

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Intussusception in children: current concepts in diagnosis and enema reduction.

Radiographics : a review publication of the Radiological Society of North America, Inc, 1999

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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