Storage Temperature for Metoprolol (Betaloc) Injection
Metoprolol tartrate injection must be stored at 20°C to 25°C (68°F to 77°F) at controlled room temperature, protected from light, and must not be frozen. 1
Official Storage Requirements
The FDA-approved labeling for metoprolol tartrate injection specifies the following storage conditions:
- Temperature range: 20°C to 25°C (68°F to 77°F), following USP Controlled Room Temperature standards 1
- Light protection: Must be protected from light and retained in the original carton until time of use 1
- Freezing: Do not freeze the injection 1
Stability Data Supporting Storage Recommendations
Research evidence confirms the stability of metoprolol injection under various conditions:
- Undiluted metoprolol injection (1 mg/mL) retained at least 99% of initial concentration when stored at room temperature for 30 hours 2
- Diluted preparations (0.5 mg/mL) in both 0.9% sodium chloride and 5% dextrose maintained stability at room temperature for at least 30 hours with no pH changes, color changes, or precipitation 2
Practical Considerations
While the official storage requirement is room temperature (20-25°C), this differs from some other injectable medications:
- Unlike insulin, which requires refrigeration at 2-8°C for unopened vials 3, metoprolol injection is stored at room temperature
- Unlike PCSK9 inhibitors, which must be transported at 2-8°C 3, metoprolol does not require cold chain management
- The injection should remain in its protective carton until immediately before use to ensure light protection 1
Common Pitfalls to Avoid
- Do not refrigerate or freeze metoprolol injection, as this is outside the specified storage range 1
- Do not expose to direct light during storage; keep in the original carton 1
- Ensure storage areas maintain consistent room temperature within the 20-25°C range, as household storage areas may fluctuate outside this range