Ofloxacin-Tinidazole (Oflox TZ) Dosing for Adults
The standard adult dose of Oflox TZ is ofloxacin 300 mg combined with tinidazole (typically 500-600 mg) taken orally twice daily for 5-7 days, depending on the specific infection being treated.
Ofloxacin Component Dosing
The ofloxacin component follows established CDC and FDA guidelines for various infections:
For Sexually Transmitted Infections
- Urethritis/Cervicitis (Chlamydia): Ofloxacin 300 mg orally twice daily for 7 days as an alternative regimen 1
- Epididymitis: Ofloxacin 300 mg orally twice daily for 10 days when enteric organisms are suspected or in patients allergic to cephalosporins/tetracyclines 1
- Pelvic Inflammatory Disease: Ofloxacin 400 mg every 12 hours for 10-14 days 2
For Other Bacterial Infections
- Complicated UTI: 200 mg three times daily (600 mg total) for up to 14 days based on clinical response 3
- Respiratory tract infections: 300-600 mg daily in divided doses for 6-14 days 4
- Severe infections: 400-800 mg daily (divided doses) for 10 days to several months depending on infection severity 5
Tinidazole Component
While the provided evidence focuses on ofloxacin, the tinidazole component in combination tablets typically provides coverage for anaerobic bacteria and protozoal infections. The combination is commonly used for mixed aerobic-anaerobic infections, particularly gastrointestinal and genitourinary infections.
Key Clinical Considerations
Important Contraindications
- Pregnancy: Ofloxacin is contraindicated in pregnant women 1
- Adolescents: Not recommended for patients ≤17 years of age due to cartilage development concerns 1
Administration Guidelines
- Can be taken with or without food 3
- For gastrointestinal side effects, consider taking with meals or at bedtime 3
- Complete the full course even if symptoms improve early 1
Common Pitfalls to Avoid
- Underdosing: Using 200 mg twice daily when 300 mg twice daily is indicated for STIs may lead to treatment failure 1
- Inadequate duration: Stopping treatment early (before 5-7 days) increases risk of recurrence 3, 6
- Ignoring resistance patterns: Ofloxacin resistance can develop, particularly with Pseudomonas aeruginosa (17.9% in one study) 5
Monitoring
- Patients should abstain from sexual intercourse until therapy is completed and symptoms resolve 1
- Re-evaluation is warranted if no improvement occurs within 3 days 1
- Partners should be evaluated and treated concurrently for STIs 1