What is the price of Premarin (conjugated estrogens) cream in [LOCATION]?

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Last updated: November 25, 2025View editorial policy

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Premarin Cream Pricing Information

I cannot provide specific pricing for Premarin cream in your location, as pharmaceutical costs vary significantly by region, insurance coverage, pharmacy, and time period, and the evidence provided does not contain current location-specific pricing data.

General Cost Considerations

Medication pricing for hormone therapies demonstrates substantial variation based on multiple factors, and patients should contact pharmacies directly or consult their insurance formulary for accurate current costs. 1

Factors Affecting Out-of-Pocket Costs

  • Insurance coverage type significantly impacts final cost - Medicare Part D, private insurance, and pharmacy benefit manager formulary placement all determine copay requirements 2, 1
  • Different pharmacies may charge different prices even with the same insurance plan, making price comparison essential 2
  • Generic versus brand formulations can show dramatic price differences, with some medications demonstrating 40-fold variations between generic and brand options 1

Practical Steps to Determine Current Pricing

  • Contact the manufacturer (Pfizer/Wyeth) directly for patient assistance programs and current wholesale pricing information 1
  • Check your pharmacy benefit manager formulary to determine tier placement and specific copay requirements for your insurance plan 1, 3
  • Consult current wholesale acquisition cost databases through your healthcare provider or pharmacist 3
  • Compare prices across multiple pharmacies in your area, including preferred and non-preferred pharmacy networks 2

Clinical Context

  • Premarin cream contains 0.625 mg conjugated estrogens per gram and is FDA-approved for treatment of moderate to severe dyspareunia due to vulvar and vaginal atrophy associated with menopause 4
  • Low-dose regimens (0.3 mg daily or twice weekly) have demonstrated efficacy and endometrial safety over 52 weeks of treatment 5
  • Alternative non-hormonal options like hyaluronic acid vaginal cream may be considered for patients who cannot or prefer not to use hormonal therapy 6

References

Guideline

Cost of Lisdexamfetamine (Vyvanse)

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Cost of Lokelma 5 mg Once Daily

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Conjugated estrogens (Premarin) vaginal cream.

The Medical letter on drugs and therapeutics, 2009

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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