What is the recommended dose of Montair LC (Levocetirizine and Montelukast) for a 13-year-old female patient weighing 39 kg?

Montair LC Dosing for 13-Year-Old Female (39 kg)

For a 13-year-old female weighing 39 kg, the recommended dose of Montair LC (combination of Montelukast and Levocetirizine) is one tablet containing Montelukast 10 mg and Levocetirizine 5 mg, taken once daily in the evening.

Montelukast Component Dosing

• At 13 years of age and 39 kg body weight, this patient should receive Montelukast 10 mg once daily, which is the standard adult dose used for patients ≥15 years of age 1, 2

• The 10 mg film-coated tablet dose is appropriate because:

  • Children ≥6 years weighing >40 kg receive the adult 10 mg dose 1, 2
  • At 39 kg, this patient is at the threshold where the adult dose becomes appropriate 1
  • The 5 mg chewable tablet (used for children 6-14 years) was designed to provide comparable systemic exposure to the adult 10 mg dose in younger/smaller children 1, 2
  • Given her age (13 years) and near-adult weight (39 kg), the 10 mg adult formulation is the appropriate choice 2

• Montelukast can be administered either in the morning or evening with equal efficacy, though evening dosing is traditionally recommended 3

Levocetirizine Component Dosing

• The standard dose of Levocetirizine for adolescents ≥12 years is 5 mg once daily 4

• This 5 mg dose is appropriate for patients weighing ≥30 kg and aged ≥12 years 4

• The combination of Levocetirizine 5 mg with Montelukast 10 mg has been studied and shown to be effective and well-tolerated in chronic urticaria with better quality of life outcomes compared to higher antihistamine doses alone 4

Administration Guidelines

• Administer as a single tablet once daily, preferably in the evening 3, 2

• The medication can be taken with or without food 3

• Ensure consistent daily administration for optimal therapeutic effect 3, 2

Important Clinical Considerations

• This patient's weight (39 kg) places her at the transition point between pediatric and adult dosing, making the adult formulation (10 mg Montelukast + 5 mg Levocetirizine) the most appropriate choice 1, 2

• The combination tablet provides the convenience of once-daily dosing with both medications in a single formulation 4

• Monitor for common side effects including sedation (though less common with levocetirizine at standard doses) 4