Gynazole (Butoconazole) Dosing for Vaginal Yeast Infections
The recommended dose of Gynazole (butoconazole nitrate 2% vaginal cream) is one applicatorful (approximately 5 grams containing 100 mg of butoconazole nitrate) administered intravaginally as a single dose. 1
Administration Details
- Apply one full applicator of butoconazole nitrate 2% cream intravaginally as a single application to the posterior vaginal fornix 1
- This single-dose formulation uses a bioadhesive, sustained-release delivery system that maintains therapeutic levels over several days 2, 3
Clinical Efficacy of Single-Dose Therapy
- Single-dose butoconazole provides rapid symptom relief, with median time to first symptom relief at 17.5 hours compared to 22.9 hours for oral fluconazole 2
- By 24 hours post-treatment, 72.8% of patients report first relief of symptoms 2
- Clinical cure rates at 8-10 days post-treatment reach 92%, with negative fungal cultures in 87% of patients 3
- At 30-day follow-up, 88% of patients remain clinically cured with 74% maintaining negative cultures 3
Advantages Over Multi-Day Regimens
- The single-dose formulation improves patient compliance compared to 3-day or 7-day treatment courses 4
- Severe symptoms decline from 20% at baseline to 6% by day 1 and 3% by day 4 after single application 3
- Symptom relief occurs significantly faster with single-dose butoconazole compared to the first dose of multi-day miconazole therapy (P = 0.01) 3
Safety Profile
- Local adverse events are minimal, with vulvovaginal pruritus and burning being the most common drug-related effects 2
- Butoconazole demonstrates fewer overall adverse events compared to oral fluconazole 2
- Only 2 out of 223 patients discontinued treatment due to increased vulvovaginal irritation in clinical trials 4
Important Clinical Caveats
- If symptoms persist beyond 7 days, reassess the diagnosis as alternative etiologies should be considered 5
- Follow-up is only needed if symptoms persist after treatment completion or recur within 2 months 5
- As with other azole vaginal preparations, butoconazole cream may weaken latex condoms and diaphragms 6