Initial Treatment for Anterolisthesis
The initial treatment for anterolisthesis should be conservative management for at least 6 weeks to 3 months, consisting of structured physical therapy with flexion-based exercises, anti-inflammatory medications, activity modification, and consideration of epidural steroid injections for radicular symptoms. 1, 2
Conservative Management Protocol
Physical Therapy - First-Line Treatment
- Flexion-based exercises are superior to extension exercises for spondylolisthesis, with 62% recovery rates at 3 years compared to 0% with extension exercises 3
- Formal physical therapy should include:
- Duration: Minimum 6 weeks of structured therapy before considering surgical options 1, 2
Pharmacologic Management
- Start with acetaminophen and/or oral NSAIDs for pain control 1
- NSAIDs demonstrate superiority over acetaminophen for moderate-to-severe pain 1
- Consider duloxetine (30-60 mg daily) as an adjunct or alternative, particularly for chronic pain that persists beyond initial treatment 1
- Avoid opioids including tramadol due to limited benefit and high adverse event risk 1
Interventional Options for Persistent Symptoms
- Epidural steroid injections may provide short-term relief (less than 2 weeks) for radicular symptoms, though evidence is limited for isolated back pain 2
- Facet joint injections can be both diagnostic and therapeutic, as facet-mediated pain accounts for 9-42% of chronic low back pain in degenerative disease 2
- Transforaminal injections are appropriate for nerve root-specific symptoms 5, 6
Duration and Progression of Conservative Care
Conservative management should continue for 3-6 months before considering surgical intervention 2, 6. The comprehensive approach must include:
- Formal physical therapy (not just home exercises)
- Trial of neuroleptic medications (gabapentin or pregabalin) if radicular symptoms present 2
- Anti-inflammatory therapy
- Activity modification and patient education 3
When to Consider Surgical Referral
Surgical evaluation is appropriate only after failed conservative management when patients have:
- Persistent disabling symptoms despite 3-6 months of comprehensive conservative care 2
- Progressive neurological deficits
- Documented instability on flexion-extension radiographs 2
- Imaging findings that correlate with clinical symptoms 1, 2
Critical Pitfalls to Avoid
- Do not prescribe extension exercises - these have demonstrated 0% recovery rates at long-term follow-up compared to 62% with flexion exercises 3
- Do not rush to imaging - MRI is indicated only after 6 weeks of failed conservative therapy in candidates for surgery or intervention 1
- Do not use opioids as first-line therapy - they show limited benefit with significantly higher adverse events (relative risk 1.28-1.69) 1
- Ensure "formal physical therapy" is completed - home exercises alone do not constitute adequate conservative management 2