How many pens of vLantus (insulin glargine) SoloStar 100 units/mL solution are needed for a 30-day supply, given a dose of 44 units in the morning and 46 units before bed?

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Lantus SoloStar Pen Calculation for 30-Day Supply

You need to dispense 6 pens of Lantus SoloStar 100 units/mL for this 30-day prescription.

Calculation Breakdown

Total daily insulin requirement:

  • Morning dose: 44 units
  • Bedtime dose: 46 units
  • Total per day: 90 units 1

Total 30-day requirement:

  • 90 units/day × 30 days = 2,700 units total 1

Lantus SoloStar pen capacity:

  • Each pen contains 300 units of insulin glargine 100 units/mL 1

Number of pens needed:

  • 2,700 units ÷ 300 units per pen = 9 pens required
  • However, the prescription states "Dispense: 60" which appears to be an error

Critical Prescribing Issue

This prescription contains a significant dosing error that requires immediate clarification with the prescriber 2, 3:

  • Lantus (insulin glargine) is a long-acting basal insulin designed for once-daily administration, not twice daily 4, 5, 6, 7
  • The pharmacokinetic profile provides a relatively constant basal level for approximately 24 hours without pronounced peaks 4, 6, 7
  • Administering Lantus twice daily at these doses (total 90 units/day) suggests either a prescribing error or an unusual clinical scenario requiring verification 5, 8

The standard approach would be:

  • Single daily dose of basal insulin (typically 40-60% of total daily dose if on basal-bolus regimen) 2
  • If 90 units total daily dose is appropriate, this should typically be given as one injection, not split 5, 6

Before dispensing, verify with prescriber:

  • Whether twice-daily Lantus dosing is intentional (occasionally used in highly insulin-resistant patients) 5
  • Whether rapid-acting insulin was intended instead of Lantus for the mealtime doses 2, 3

Correct Dispensing Quantity

If the prescription is verified as correct: dispense 9 pens (not 60 as written) to provide adequate supply for the 2,700 units needed over 30 days 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Insulin Dosing Guidelines for Adults with Diabetes Mellitus

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Insulin Lispro Administration and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Insulin glargine (Lantus).

International journal of clinical practice, 2002

Research

Insulin Glargine: a review 8 years after its introduction.

Expert opinion on pharmacotherapy, 2009

Research

Insulin glargine versus NPH insulin in patients with type 1 diabetes.

Drugs of today (Barcelona, Spain : 1998), 2003

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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